Birgid Schlindwein's
Hypermedia Glossary Of Genetic Terms
Search Results
Birgid Schlindwein'sHypermedia Glossary Of Genetic TermsSearch Results |
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| Library | An unordered collection of clones (i.e., cloned DNA from a particular organism), whose relationship to each other can be established by physical mapping. Compare genomic library, arrayed library. |
| Clone bank | See genomic library. |
| Physical map | A map of the locations of identifiable landmarks on DNA (e.g., restriction enzyme cutting sites, genes), regardless of inheritance. Landmarks include restriction endonuclease recognition sites, DNA sequence and chromosomal bands. Distance is measured in base pairs. For the human genome, the lowest-resolution physical map is the banding patterns on the 24 different chromosomes; the highest-resolution map would be the complete nucleotide sequence of the chromosomes. |
| Genomic library | A collection of clones made from a set of randomly generated overlapping DNA fragments representing the entire genome of an organism. Compare library, arrayed library. |
| Arrayed library | Individual primary recombinant clones (hosted in phage, cosmid, YAC, or other vector) that are placed in two-dimensional arrays in microtiter dishes. Each primary clone can be identified by the identity of the plate and the clone location (row and column) on that plate. Arrayed libraries of clones can be used for many applications, including screening for a specific gene or genomic region of interest as well as for physical mapping. Information gathered on individual clones from physical map analyses is entered into a relational database and used to construct physical and genetic linkage maps simultaneously; clone identifiers serve to interrelate the multilevel maps. Cf. library, genomic library. |