Birgid Schlindwein's
Hypermedia Glossary Of Genetic Terms
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Birgid Schlindwein'sHypermedia Glossary Of Genetic TermsSearch Results |
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| Heteroduplex analysis | The study of the mobilities of heteroduplex DNA under polyacrilamide gel electrophoresis. The reduced mobility of heteroduplex DNA compared with homoduplex DNA is proportional to the degree of divergence of the sequences. |
| Heteroduplex DNA | A double-stranded DNA molecule or a DNA/RNA hybrid where each strand is from a different source. |
| Deoxyribonucleic acid (DNA) | The molecule that encodes genetic information. DNA is a double-stranded molecule held together by weak bonds between base pairs of nucleotides. The four nucleotides in DNA contain the bases: adenine (A), guanine (G), cytosine (C), and thymine (T). In nature, base pairs form only between A and T and between G and C; thus the base sequence of each single strand can be deduced from that of its partner. |
| Electrophoresis | A method of separating large molecules (such as DNA fragments, peptides or proteins) from a mixture of similar molecules. An electric current is passed through a medium containing the mixture, and each kind of molecule travels through the medium at a different rate, depending on its electrical charge and size. Separation is based on these differences; typically smaller fragments travel farther through the media (gel) in which separation is carried out. Agarose and acrylamide gels are the media commonly used for electrophoresis of proteins and nucleic acids. |
| Homoduplex DNA | A double-stranded DNA molecule where both strands are from the same source. Cf. heteroduplex DNA. |
| DNA sequence | The relative order of base pairs, whether in a fragment of DNA, a gene, a chromosome, or an entire genome. See base sequence. |