Birgid Schlindwein's
Hypermedia Glossary Of Genetic Terms
Search Results
Birgid Schlindwein'sHypermedia Glossary Of Genetic TermsSearch Results |
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| Linkage equilibrium | When the observed frequencies of haplotypes in a population agrees with haplotype frequencies predicted by multiplying the frequencies of individual genetic markers in each haplotype. Cf. linkage disequilibrium. |
| Haplotype | A set of closely linked genetic markers present on one chromosome which tend to be inherited together (not easily separable by recombination). Some haplotypes may be in linkage disequilibrium. |
| Population | A group of organisms of the same species relatively isolated from other groups of the same species. See deme. |
| Marker | An identifiable physical location on a chromosome (e.g., restriction enzyme cutting site, gene, minisatellite, microsatellite) whose inheritance can be monitored. Markers can be expressed regions of DNA (genes) or some segment of DNA with no known coding function but whose pattern of inheritance can be determined. See RFLP, restriction fragment length polymorphism. |
| Linkage | An association in inheritance between characters such that the parental character combinations appear among the progeny more often than the non-parental. The proximity of two or more markers (e.g. genes, RFLP markers) on a chromosome; the closer together the markers are, the lower the probability that they will be separated during DNA repair or replication processes (binary fission in prokaryotes, mitosis or meiosis in eukaryotes), and hence the greater the probability that they will be inherited together. Cf. recombination, complete linkage, partial linkage, non-linkage, linkage equilibrium, linkage disequilibrium. |
| Linkage disequilibrium | When the observed frequencies of haplotypes in a population does not agree with haplotype frequencies predicted by multiplying together the frequency of individual genetic markers in each haplotype. This results from a more or less recent mutation in one of two linked alleles. So some allele combinations occure more frequnetly than others. The disequilibrium decreases from generation to generation by crossing over and recombination. Cf. linkage equilibrium. |